![]() Their prompt identification is of primary importance for directing supportive care efforts and maintaining dose intensity while minimizing the morbidity associated with supportive care interventions. The latter are noteworthy for their potential to exhibit malignant features, and they may necessitate invasive treatment. The use of BRAF inhibitors may lead to the development of cutaneous toxicities such as rashes, photosensitivity, alopecia, palmoplantar erythrodysesthesia, and proliferative skin lesions, including keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cuSCCs). Further research is warranted regarding the pathogenesis of diabetic nephropathy and indication of kidney biopsy in diabetic cases.Ĭlinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients.īelum, Viswanath Reddy Rosen, Alyx C Jaimes, Natalia Dranitsaris, George Pulitzer, Melissa P Busam, Klaus J Marghoob, Ashfaq A Carvajal, Richard D Chapman, Paul B Lacouture, Mario E Because it is so difficult to clearly distinguish pure kidney lesions caused by diabetes and kidney lesions due to effects other than diabetes, it is vital that these overlapped pathological findings be confirmed on kidney biopsy in cases of early stage diabetes. Moreover, comparison of the clinico-pathological findings of diabetic nephropathy with hypertensive nephrosclerosis revealed that there are few differences in their pathological findings in cases with low albuminuria and preserved estimated glomerular filtration rate (eGFR). Recent clinico-pathological study with kidney biopsy samples from diabetic patients revealed that pathological changes of diabetic nephropathy are characteristic and have special impacts on prognosis in each clinical stage. Therefore, risk classification with clinical data and pathological findings is important. However, the onset of kidney disorder and the progression pattern of kidney dysfunction and proteinuria greatly vary cases by cases. ![]() ![]() There are presented the main clinico-roentgenological signs of the chest damage in the injured persons, suffering polytrauma, according to the data from the specialized department of traumatic shock and polytrauma.Ĭlinico-pathological features of kidney disease in diabetic cases.įuruichi, Kengo Shimizu, Miho Okada, Hirokazu Narita, Ichiei Wada, Takashiĭiabetic kidney disease is the major cause of end-stage kidney disease in developed countries. ![]() Zamiatin, P N Panchenko, E V Grigor'ian, G O Goloshchapova, E V A análise imuno-histoquÃmica revelou positividade para CD34 e Ki-67, o que, juntamente com o exame morfológico, direcionou o diagnóstico para HALE. Após a biópsia excisional, o exame histopatológico mostrou lesão bem encapsulada multilobulada com proliferação de capilares sanguÃneos com células endoteliais de aspecto epitelioide, infiltrado inflamatório difuso com linfócitos, plasmócitos, inúmeros eosinófilos e presença de folÃculos linfoides. Este trabalho relata um caso de um paciente do sexo masculino, de 50 anos, que exibia aumento de volume nodular na mucosa do lábio superior, com 3 cm de dimensão e 7 anos de evolução. Tem como principal diagnóstico diferencial a doença de Kimura. Sua etiopatogenia permanece indefinida, sendo descrita como proliferação vascular reacional, malformação vascular ou neoplasia. Resumo A hiperplasia angiolinfoide com eosinofilia (HALE) é considerada uma lesão vascular benigna rara que acomete, principalmente, o tecido cutâneo e subcutâneo da região de cabeça e pescoço, mas incomum na cavidade oral. Tenório, Jefferson da Rocha Gonzaga, Amanda Katarinny Goes Gonçalves, PatrÃcia Guerra Peixe de Oliveira, Denise Hélen Imaculada Pereira Queiroz, Lélia Maria Guedes Hiperplasia angiolinfoide com eosinofilia: um caso raro em cavidade oral
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